C-glycosides to fused polycyclic ethers. A formal synthesis of (+/-)-hemibrevetoxin B.
نویسندگان
چکیده
This paper describes a formal total synthesis of the marine ladder toxin hemibrevetoxin B from Danishefsky's dienes. This approach couples the generation of C-glycosides from cyclic enol ethers with metathesis or acid-mediated annulation reactions. The result is a highly efficient synthesis of the tetracyclic ring system of hemibrevetoxin B.
منابع مشابه
C-glycosides to fused polycyclic ethers. An efficient entry into the A-D ring system of gambierol.
[reaction: see text]. This Letter describes our use of C-glycosides to synthesize the A-D ring system of the marine ladder toxin gambierol in 20 steps.
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ورودعنوان ژورنال:
- The Journal of organic chemistry
دوره 66 4 شماره
صفحات -
تاریخ انتشار 2001