C-glycosides to fused polycyclic ethers. A formal synthesis of (+/-)-hemibrevetoxin B.

نویسندگان

  • J D Rainier
  • S P Allwein
  • J M Cox
چکیده

This paper describes a formal total synthesis of the marine ladder toxin hemibrevetoxin B from Danishefsky's dienes. This approach couples the generation of C-glycosides from cyclic enol ethers with metathesis or acid-mediated annulation reactions. The result is a highly efficient synthesis of the tetracyclic ring system of hemibrevetoxin B.

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عنوان ژورنال:
  • The Journal of organic chemistry

دوره 66 4  شماره 

صفحات  -

تاریخ انتشار 2001